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Top Protein Skimmers Under $300 and up to 75 Gallons of Reef Tank - BRStv Buyer's Guide ; Reef Octopus Classic 110INT 4” Internal Protein Skimmer. Reef Octopus. Learn about protein skimmers and selecting the right one for your reef. Detailed buyer's guide and skimmer reviews for HOB, in-tank, and recirculating The size of your aquarium determines the kind of protein skimmer you need. So before you spend your money on a skimmer, ask yourself, how much aquarium space doTop 5 Tips for Choosing the Right Protein Skimmer · #1: Aquarium Size · #2: Bioload · #3: Space · #4: Budget · #5: Bigger is Not Always Better.