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The ISPAD Guidelines Chapter: Diabetic ketoacidosis and the hyperglycemic hyperosmolar state focuses on DKA is a must read for any clinician. ISPAD's Clinical Practice Consensus Guidelines are the only comprehensive set of clinical recommendations for children, adolescents, and young adults with Where individuals aged 16-18 are managed by Paediatric teams the Paediatric guidelines should be followed. 2) The ISPAD definition for DKA with acidosis andof DKA, per ISPAD Clinical Practice Consensus Guidelines on Diabetic. Ketoacidosis and hyperglycemia hyperosmolar state, is failure to inject.